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Diseases arising from mutations in intermediate filament (IF) genes affect various tissues due to the role of intermediate filaments in maintaining cell structure and integrity. Intermediate filaments are part of the cytoskeleton and include proteins like keratins, desmin, vimentin, neurofilaments, and lamins , each found in different tissues. Mutations in genes encoding these proteins can cause several genetic disorders, commonly affecting skin, muscle, nerves, and other tissues. 1. Keratins (found in epithelial cells) Epidermolysis Bullosa Simplex (EBS) : Caused by mutations in KRT5 and KRT14 genes that encode keratins 5 and 14. Characterized by fragile skin , where minor trauma causes blistering due to the weakening of cell adhesion in the basal layer of the epidermis. Pachyonychia Congenita : Mutations in KRT6A , KRT6B , KRT16 , or KRT17 lead to this disorder, marked by thickened nails, painful calluses , and oral lesions. These keratin mutations disrupt the integrity of ...

Will technology eventually replace us ?

January 09, 2024

That is a very interesting and complex question. There is no definitive answer, as different perspectives may have different opinions on the role and impact of technology on human society. Some may argue that technology will eventually replace us, as it becomes more advanced, autonomous, and intelligent, and takes over many of the tasks and functions that humans currently perform. Others may contend that technology will not replace us, but rather augment and enhance our capabilities, creativity, and productivity, and enable us to solve the most pressing challenges of our time. According to some web search results 1 2 3 4 , there are various factors that may influence the future relationship between technology and humanity, such as the pace and direction of innovation, the ethical and social implications of artificial intelligence, the distribution and accessibility of resources and opportunities, the resilience and adaptability of human culture and values, and the potential for co...

Daily one liner current affairs 5 October 2023

October 05, 2023

Daily one liner current affairs 5 October 2023 👉 What percentage has been projected by the World Bank for India's growth rate in the current financial year - 6.3%. 👉 India's first solar rooftop cycling track has been built in - Hyderabad 👉 National Turmeric Board and Central Tribal University will be set up in which state - Telangana 👉 What is the theme of Abu Dhabi International Petroleum Exhibition and Conference - Decarbonising, Fast, Together. 👉 Name the Indian athlete who has won the gold medal in shotput event at the ongoing Asian Games in China - Tajinderpal Singh Toor. 👉 Who has been appointed as the Chairman of Advertising Standards Council of India - Saugata Gupta. 👉 Who has been appointed as the Deputy Chief of naval staff - Tarun Sobti. 👉 Who has recently been appointed as the Director General of Border Roads Organisation - Raghu Srinivasan. 👉 The Nobel Prize for Medicine for the year 2023 has been awarded to - 2 persons....